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Low calorie diet weight loss maintenance trial:

No special food can definitely promote weight maintenance.

David Stewart
Thursday, June 1, 2017
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  • In the context of these 2 common weight loss diet approaches, neither of the 2 hypothesized predisposing factors was helpful in identifying which diet was better for whom. The primary outcome was month weight change.

  • Subjects Obesity Therapeutics Weight management. Lifestyle modification for obesity: new developments in diet, physical activity, and behavior therapy.

  • Statistical model eTable 1. Participants who lost a mean 5.

  • Epub Jul 6. Liraglutide, a once-daily human glucagon-like peptide-1 analog, induced clinically meaningful weight loss in a phase 2 study in obese individuals without diabetes.

Publication types

J Altern Complement Med. All were considered unlikely to be related to treatment based either on proximity of occurrence to first dose or there having been a pre-existing condition. Further research to find strategies in obesity management focusing on successful maintenance of weight loss is needed.

Relationship of insulin dynamics to body composition and resting energy expenditure following weight loss. Dier study participants provided written informed consent. Concentrations of many lipids, notably total- and low-density lipoprotein cholesterol, typically heart diet to lose weight before surgery their nadir during the early weeks of dieting, reflecting the effects of caloric restriction, as well as weight loss. An Erratum to this article was published on 14 October Bax Nature Reviews Cardiology Estimating and reporting treatment effects in clinical trials for weight management: using estimands to interpret effects of intercurrent events and missing data Sean WhartonArne AstrupLars EndahlMichael E. This study had several strengths. Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial.

Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: A 1-y study. Thyroid neoplasms were calprie by three participants in the liraglutide group. Download citation. Further study is needed of the frequency of medication usage required to facilitate weight loss maintenance. Of 18 participants in each group who withdrew because of an AE, only six participants did so because of serious events: ischemic colitis, worsening cholelithiasis, ovarian cancer, papillary thyroid carcinoma and bilateral breast cancer in the liraglutide group, and acute appendicitis in the placebo group. Some special behaviors are also associated with better weight loss maintenance. No special food can definitely promote weight maintenance.

Background

If data are missing, we will attempt to contact the authors through e-mails to obtain missing data or additional information twice, 1 week apart. Epub Jun The flow of the participants through the trial appears in Figure 1. Epub Nov

Baker Authors Sara Beigrezaei View author publications. To address this, the study was broadly advertised and successfully enrolled participants with relatively good ethnic and racial diversity, and a range, albeit limited, of educational attainment. Epub Feb For the hypotheses involving diet and genotype or diet and baseline INSan additional fixed effect was added for genotype or baseline INSalong with all 2- and 3-way interactions model appears in eAppendix 4 in Supplement 2.

  • Randomized trial of lifestyle modification and pharmacotherapy for obesity. Arch Intern Med.

  • Skip to main content Thank you for visiting nature. Conclusion: Liraglutide, with diet and exercise, maintained weight loss achieved by caloric restriction and induced further weight loss over 56 weeks.

  • In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Int J Obes. To identify studies regarding weight maintenance, with an emphasis on dietary interventions, a complete search of articles was carried out by using PubMed and SCOPUS.

  • A safety committee for data surveillance was established by the sponsor. Similarly, the test for interaction among diet, baseline insulin secretion INSand the month time point was not statistically significant.

We should note the limitation of these studies such as self-reported data, more lpw of men than women in the study, wwight design, no representative sample, dropout rate, motivated participants, and low dietary compliance. S, screening period; F, follow-up. The reduction in SBP achieved during run-in was maintained to a greater extent with liraglutide than placebo, but the mechanism responsible for the reduction remains unknown. Psychiatric disorders occurred in 24 A meta-analysis inrevealed that using a very low energy die t VLED for weight loss or losing more than 20 kg are two predictors of weight maintenance,[ 9 ] however, one study that assessed the method of weight loss, declared that patients on VLED gain more weight after the end of the weight loss period, but a self-directed approach was more successful in this regard. Diets such as DASH or addition of components like gelatin, capsaicin, and green tea have been tried for weight maintenance, but they need more investigation to clarify their long-term effects. GI events, including nausea, accounted for the greatest number of study withdrawals from liraglutide, whereas the onset of T2D accounted for most withdrawals from placebo.

King, PhD 1,3. Despite the well-known benefits of exercise, the increase in energy expenditure and the potential to decrease hunger and energy intake exercise alone does not seem to be effective at modifying weight status [ 161718 ]. Revised : 15 April Skip to main content. The effects of weight loss approaches on bone mineral density in adults: a systematic review and meta-analysis of randomized controlled trials. Analysis of Longitudinal Data. Int J Obes 37, —

Introduction

Author information Article notes Copyright and License information Disclaimer. J Altern Complement Med. Sixteen participants exhibited symptomatic hypoglycemia; 11 participants receiving liraglutide reported 18 events, and 5 participants on placebo reported 7 events. References 1 World Health Organization.

  • Epub Jul 6. All study participants provided written informed consent.

  • Liraglutide, with diet and exercise, maintained weight loss achieved by caloric restriction and induced further weight loss over 56 weeks.

  • Create a free personal account to access your subscriptions, sign up for alerts, and more. Health status determinants: lifestyle, environment, health care resources and efficiency.

  • The olw biological reasons for the rapid weight regain may be that weight loss causes a decrease in total energy expenditure to a degree that is greater than predicted from the decrease in fat and lean mass [15,16] in combination with increased appetite in the weight-reduced state [17,18]. Weight change trajectories for the diet-genotype pattern subgroups are presented in eFigure 2A and for diet and INS tertile subgroups in eFigure 2B in Supplement 2.

High white blood cell count is associated with a worsening of insulin trisl and predicts the development of type 2 diabetes. We envisage that this systematic review and meta-analysis will provide valuable information regarding the effectiveness of adding exercise to weight loss diets. The month changes in low-density lipoprotein cholesterol concentrations significantly favored a healthy low-fat diet. Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the other funders. Study record managers: refer to the Data Element Definitions if submitting registration or results information.

World Health Organization. Out-of-window visits occurred for five participants at week 56 and 10 participant at week In addition, another systematic review dket the effects of diet or exercise or both on excessive weight gain during pregnancy and showed that diet or exercise alone and diet plus exercise during pregnancy appears to reduce the risk of excessive gestational weight gain [ 39 ]. Actual Enrollment :. Bandura A. References 1 World Health Organization.

  • There were no severe psychiatric disorders among participants receiving liraglutide, compared with three disorders in three participants taking placebo depression, major depression and stress. Figure 2a shows mean percentage change in body weight from screening to week 68 which includes the week off-drug period.

  • Predictors of long-term weight maintenance. Two approaches facilitate the maintenance of lost weight.

  • At year 2, those who had been switched to placebo had regained most of their lost weight, whereas those who remained on medication sustained a significantly greater weight loss.

  • Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

  • Listing a study does not mean it has been evaluated by the U. Supplementary information.

  • Search for terms.

Values approached near-randomization levels after longer treatment duration after week Effects of matched doet loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial. Lancet ; : — Individual exercise includes aerobic exercise and general physical activity e. Supervised sessions include structured exercise with a duration of 45 min.

Sessions were held weekly for 8 weeks, then every 2 weeks for 2 months, then every 3 weeks until the sixth month, and monthly thereafter. Effects of a low-glycemic load vs low-fat diet in obese young adults: a randomized trial. However, these studies were limited by relatively small sample sizes or post hoc analyses of the results. The overall quality of studies will be classified as low risk low risk for all domainsunclear risk unclear for at least one domainand high risk high risk for at least one domain. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

Publications

Google Scholar Crossref. In addition, losd systematic review evaluated the effects of diet or exercise or both on excessive weight gain during pregnancy and showed that diet or exercise alone and diet plus exercise during pregnancy appears to reduce the risk of excessive gestational weight gain [ 39 ]. Hide detailed description. Control Clin Trials.

Study Description. Higgins JP, Maintenacne S. The multilocus genotypes were grouped into those predicted to be more sensitive to fat low-fat genotype; patternsmore sensitive to carbohydrates low-carbohydrate genotype; patternsor sensitive to neither genotype pattern Cell Metab. Weight gain and impaired glucose metabolism in women are predicted by inefficient subcutaneous fat cell lipolysis.

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To address this, the study low calorie diet weight loss maintenance trial broadly advertised and successfully enrolled participants with relatively good ethnic and racial diversity, and a range, albeit limited, of educational attainment. The aforementioned trials of lorcaserin and orlistat underscore that weight loss medications must triaal be taken long-term in order to maintain the initial weight losses achieved. Pulse began to return toward the randomization level at week J Stat Softw. Protocol Open Access Published: 20 April The effects of exercise and low-calorie diets compared with low-calorie diets alone on health: a protocol for systematic reviews and meta-analyses of controlled clinical trials Sara Beigrezaei 12Zeinab Yazdanpanah 12Sepideh Soltani 3Seyede Hamide Rajaie 12Sahar Mohseni-Takalloo 124Tayebeh Zohrabi 12Mojtaba Kaviani 5Scott C.

Am J Clin Nutr dirt 95 : — Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Mariman EC. Diets with a meal replacement approach have some limitations, which have been mentioned previously. Mean scores at week 56 with the last-observation-carried-forward analysis were similar to those observed at randomization for both liraglutide- 1.

The liraglutide group kow with placebo also low calorie diet weight loss maintenance trial greater mean absolute weight loss 6. Individuals who withdrew from the trial were asked to return at week 56 after randomization for follow-up weight assessment. An energy-restricted diet, with moderate fat, may have more advantages for weight maintenance rather than a low-fat one. A drop in hormones levels, such as leptin and thyroid hormones, causes the risk of increased energy intake after weight loss. Further reading Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging Arnold C.

References 1 World Health Organization. Prev Med. J Nutrigenet Nutrigenomics. Thyroid neoplasms were reported by three participants in the liraglutide group. Multicenter, placebo-controlled trial of lorcaserin for weight management.

The definition of weight maintenance. A structured diet and exercise program promotes favorable changes in weight loss, body composition, and weight maintenance. In patients with T2D, treatment with liraglutide 1. Some special foods have been suggested for weight maintenance.

Correspondence to T A Wadden. Two of 21 participants with treatment compliance deviations missed doses or incorrect dosing were withdrawn; seven participants were excluded from the per-protocol maimtenance. At week 56 the end of the double-blind periodthe liraglutide group lost an additional mean 6. We should note the limitation of these studies such as self-reported data, more proportion of men than women in the study, their design, no representative sample, dropout rate, motivated participants, and low dietary compliance. Thyroid neoplasms were reported by three participants in the liraglutide group.

Nausea was transient, with most incidents occurring during the first 4 weeks of treatment, coinciding with dose escalation Supplementary Figure 2. Trial loss with a low-carbohydrate, Mediterranean, or low-fat diet. Dietary Intake by Caoorie Point. Both analysis models included treatment, sex, country and comorbidity stratification as fixed effects, and randomization value as a covariate. Strengths in study conduct included meeting and exceeding the sample size target of participants, the nearly equal proportions of women and men enrolled, high and equivalent retention for both diet groups, and comparability of change between groups in potentially important outcomes related to weight loss, such as physical activity. Results will be submitted for publication in international peer-reviewed scientific journals. Publication bias will be explored by inspecting funnel plots and by conducting asymmetry tests.

Show results from All journals This journal. Epub Dec Lifestyle counseling, on a twice-monthly or monthly basis, improves weight maintenance for up to 2. Search for terms.

Publication types

Good Clinical Practice. Dietary energy density and successful weight loss maintenance. Correspondence to T A Wadden. Liraglutide produced small but statistically significant improvements in several cardiometabolic risk factors compared with placebo.

Losing more weight during weight loss, monitoring weight, and choosing weifht weight loss maintenance are supposed to be important factors for successful weight maintenance. Comparison of patients who have maintained their weight loss more than re-gainers shows that the subjects in first group stay late less at night, have increased physical activity after weight loss, drink less sugar sweetened beverages, eat less calorie from protein, and they have more emotional support. Diabetes Therapy The randomized participants lost a mean 6. A drop in hormones levels, such as leptin and thyroid hormones, causes the risk of increased energy intake after weight loss.

Results will be submitted for publication in international peer-reviewed scientific journals. Purchase access Subscribe now. If data cannot be meta-analyzed, we will summarize the articles and conclude on high-quality studies. Publications: Obesity: preventing and managing the global epidemic.

Green tea for weight loss and weight mainttenance in overweight or obese adults. Weight change had a positive relationship with the craving score. Poor dietary compliance is one of the most common problems associated with these diets. First of all, participants in most studies are volunteers and so more motivated. Associated data ClinicalTrials. Dietary diversity score and cardiovascular risk factors in Tehranian adults. Br J Nutr.

Consuming a lower amount of sugar sweetened beverages, not being awake late at night, and consuming more healthy foods are some examples of such behaviors. The placebo-subtracted weight-loss difference of 5. Figure 2. The definition of weight maintenance.

Randomized trial of lifestyle modification and pharmacotherapy for obesity. Previous publications have shown that sleep deprivation may be associated with trual and central adiposity. Gastrointestinal GI disorders were reported more frequently with liraglutide than placebo, but most events were transient, and mild or moderate in severity. Weight regain after weight loss is a common problem for all those obese or overweight who have had a recent weight loss. View author publications.

GLP-1 has also emerged as an immunomodulatory agent [42,43]. Hide lose weight before Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Mean calcitonin levels were below the upper normal range in both groups at week 56, and the geometric mean showed little variation during the treatment period Supplementary Figure 3c. In this manuscript, we present the study protocol for a systematic review and meta-analysis to compare the effects of a low-calorie diet plus exercise with a low-calorie diet on risk factors associated with chronic diseases. Limitations include the inability to determine the precise effects of liraglutide on metabolic and CVD risk factors because of changes in these variables during the LCD run-in.

Rapid significant weight loss and regional lipid deposition: implications for insulin sensitivity. International journal of obesity. Exercise: min of moderate intensity, 75 min of vigorous intensity, or an equivalent combination of moderate and vigorous intensity exercise per week in accordance with WHO recommendations. The repeated-measures analysis included the same effects as above, plus treatment-by-visit interaction.

  • Of this 30 min will comprise of interval-based spinning session and 15 min circuit training program focusing on large muscle groups. There were 18 adverse events or serious adverse events that were evenly distributed across the 2 diet groups.

  • Psychobehavioural factors are more strongly associated with successful weight management than predetermined satiety effect or other characteristics of diet. Figure 1.

  • Consent for publication No individual detail is presented in this protocol; therefore, it is not applicable.

  • The same set of scales should ideally be used throughout the trial. The study also has several limitations.

Save Preferences. Similarly, GLP-1 RAs have shown antiinflammatory effects in human coronary artery endothelial cells and aortic endothelial cells [47]. Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus. About this article. Study Description. Circulating cytokines as determinants of weight loss-induced improvements in insulin sensitivity.

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Detailed Description:. A Prospective Study Fritz F. Methods and analysis: This is an investigator-initiated, randomized, placebo-controlled, parallel group trial. Epub Oct 7. No blood glucose measurements were performed, xiet the events were reported as AEs Table 5. Therefore, the purpose of this study is to investigate the maintenance of weight loss and immunometabolic health outcomes after diet-induced weight loss followed by one-year treatment with a glucagon-like peptide-1 receptor agonist liraglutidephysical exercise, or the combination of both treatments as compared with placebo in individuals with obesity. In mice, GLP-1 RA administration reduces macrophage accumulation and inflammatory markers in the arterial wall [44], adipose tissue [45], and heart [46].

Calorie restriction and bone maintenane in young, overweight individuals. Similarly, the test for interaction among diet, baseline insulin secretion INSand the month time point was not statistically significant. Comparison of continuous and intermittent anorectic therapy in obesity. Am J Health Promot. A Satterthwaite approximation for denominator degrees of freedom was used in all Wald tests. Update on prevention of cardiovascular disease in adults with type 2 diabetes mellitus in light of recent evidence: a scientific statement from the American Heart Association and the American Diabetes Association. FDA Resources.

Outcome Measures. Lpw Review reports. The sensitivity analysis will be done by sequentially removing individual studies included in the meta-analyses to assess the robustness of the meta-analyses [ 45 ]. However, weight regain reverse these health benefits [10,11]. Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss.

Do mental disorders and eating patterns affect long-term weight loss maintenance? Support Center Support Center. These may have had an impact on their final results week 56 or antibody data sampled at week Different cures such as diet therapy, behavioral therapy, exercise or a mixture of them have been advised as solutions. One case of major depression occurred in the placebo group.

With the large sample size, good retention, substantial weight loss and weight loss variability, and good adherence to and differentiation of diets, the study was well positioned to detect maintrnance interactions by the primary variables of interest if they existed. The merits of subtyping obesity: one size does not fit all. Lifestyle counseling, on a twice-monthly or monthly basis, improves weight maintenance for up to 2. Secondary outcomes included anthropometric measures, plasma lipid levels, insulin and glucose levels, and blood pressure levels. Figure 1. Focus on obesity.

Article PubMed Google Scholar 3. Results of the present trial demonstrated that the combination of liraglutide 3. Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes. Sex based subgroup differences in randomized controlled trials: empirical evidence from Cochrane meta-analyses.

Hide detailed description. King, PhD 1,3. Obes Res ; 6 Suppl 2 : 51S—S. Issue Date : November To facilitate dietary adherence, participants met face-to-face, every other week with a nutritionist and had telephone calls on alternate weeks. Epub Mar 5.

End-of-treatment differences between groups in weight change were not statistically significant. One of methods that have been used a lot for preventing weight gain is meal replacement. They also have to be supplemented because of nutrient deficiency. Int J Obes Lond ; 29 —7. No special food can definitely promote weight maintenance. Obes Res ; 7 : — You can also search for this author in PubMed Google Scholar.

Weight management using a meal replacement strategy: Meta and pooling analysis from six studies. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Dietary diversity within food groups: An indicator of specific nutrient adequacy in Tehranian women.

Tertiles were used in this Figure for ease of presentation. The increase in prevalence of obesity in recent decades is multifactorial; however, sedentary lifestyle and poor quality diets diet weight loss proposed to be the two major contributing factors [ 23 ]. Estimated Study Completion Date :. Participants were encouraged to follow current physical activity recommendations. Protocol Open Access Published: 20 April The effects of exercise and low-calorie diets compared with low-calorie diets alone on health: a protocol for systematic reviews and meta-analyses of controlled clinical trials Sara Beigrezaei 12Zeinab Yazdanpanah 12Sepideh Soltani 3Seyede Hamide Rajaie 12Sahar Mohseni-Takalloo 124Tayebeh Zohrabi 12Mojtaba Kaviani 5Scott C. PubMed Google Scholar Crossref.

Dietary habits that can help obese persons to keep their lost weight are ddiet, cognitive control, monitoring weight, correct dietary choices, high levels of physical activity, eating more low calorie-dense foods, and lower portion size. Dietary energy density is favorably associated with dietary diversity score among female university students in Isfahan. Unfortunately the sample size of this study was small. Diabetes Care ; 25 : —

INTRODUCTION

Rapid weight loss vs. Download citation. The clinical implications of the increase in pulse, which has been observed in previous trials of liraglutide and other glucagon-like peptide-1 receptor agonists, are not yet clear. Dosing was initiated at 0.

Table 1 Meal replacement and weight maintenance. Psychobehavioural factors are more strongly weigyt with successful weight management than predetermined satiety effect or other characteristics of diet. Other behaviors also need to be assessed in this regard. Participants not pre-selected in this manner may have achieved smaller long-term weight losses. Although the DASH diet has numerous health results, its effect on weight loss and maintaining it is still under dispute.

Eur J Pharmacol. Diabetes Therapy Trepanowski, PhD 1 ; Liana C. The role of diet and exercise for the maintenance of fat-free mass and resting metabolic rate during weight loss. Effects of an intensive weight loss program on knee joint loading in obese adults with knee osteoarthritis. Meta-analysis in clinical trials. Exercise prescription will be performed under strict control of the scientific personnel.

Gastrointestinal GI disorders were reported more frequently with liraglutide than placebo, but most events were transient, and mild or moderate in severity. It has been shown that a greater resting metabolic rate RMR at baseline, increased dietary restraint, and low frequency of dieting,[ 8 ] are associated with weight regain. Prolonged refeeding improves weight maintenance after weight loss with very-low-energy diets. Main meals and snacks can be replaced by these nutritionally balanced low-fat meals.

Additional rationale for the 3-SNP multilocus genotype as written at the time of 13 the original grant submission, in Corresponding Author: Christopher D. Drug: Liraglutide Daily injections 3mg with weight consultations starting at dose of 0. In the placebo group, no withdrawals were due to GI disorders. Contacts and Locations. Discussion For decades, epidemiological and clinical studies have been elucidating the link between lifestyle modifications and health outcomes through different mechanisms [ 49 ]. Two investigators will independently perform the study selection.

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The mean ratings were 4. Comput Methods Programs Biomed. Discussion We envisage that this systematic review and meta-analysis will provide valuable information regarding the effectiveness of adding exercise to weight loss diets. Obes Res. Prespecified data analysis was performed on the full analysis set, comprising all randomized individuals exposed to trial drug with at least one post-randomization weight assessment.

None of these data were analyzed statistically because they were collected before randomization. The placebo-subtracted weight-loss difference of 5. Following an investigation by Wang et al. Therefore, we conducted rrial review of the available evidence to assess the effect of different diets on weight maintenance after weight loss. The liraglutide group compared with placebo also achieved greater mean absolute weight loss 6. GI events, including nausea, accounted for the greatest number of study withdrawals from liraglutide, whereas the onset of T2D accounted for most withdrawals from placebo. One participant was determined to be referring to incidents that occurred 6 years before the trial.

Introduction

Nutrient intake during diet-induced weight loss and exercise interventions in a randomized trial in older overweight and obese adults. Front Physiol. Randomization was performed centrally using a telephone- or web-based system.

Increasing energy expenditure by increasing physical activity is the first-line lifestyle modification in the treatment of obesity along with reducing food intake. Food and Drug Administration. Quiz Ref ID In this clinical trial of generally healthy overweight or obese adults without diabetes who were randomly assigned to a healthy low-fat vs a healthy low-carbohydrate diet, there was no significant difference in weight loss at 12 months. One year treatment with GLP-1 RAs reduce the inflammation marker, high-sensitivity C-reactive protein, in overweight and obese individuals [33] and T2D patients [51].

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Principal complaints associated with the medication were transient nausea, constipation, diarrhea and vomiting, as previously observed. Topiramate: long-term maintenance of weight loss induced by a low-calorie diet in obese subjects. Show results from All journals This journal. Concentrations of many lipids, notably total- and low-density lipoprotein cholesterol, typically reach their nadir during the early weeks of dieting, reflecting the effects of caloric restriction, as well as weight loss. Prev Med.

Supplementary information. Tertiles were used in this Figure for ease of presentation. However, there were no significant between-group differences observed for body mass index, body fat percentage, and waist circumference Table 3. Diabetes Obes Metab ; 11 Suppl 3 : 26— Eight of the 11 participants withdrew due to GI events that had onset in the first 4 weeks of the trial during dose escalation. Study record managers: refer to the Data Element Definitions if submitting registration or results information.

Diab Vasc Dis Res ; 8 : — Liraglutide was generally well tolerated. Conclusions: Consistent with the carbohydrate-insulin model, lowering dietary lwo increased energy expenditure during weight loss maintenance. Meal timing and composition influence ghrelin levels, appetite scores and weight loss maintenance in overweight and obese adults. Show results from All journals This journal. Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: A 1-y study. Green tea for weight loss and weight maintenance in overweight or obese adults.

Epub Aug In analyses restricted to participants of European descent only, no significant interaction was observed by genotype pattern the 3-way interaction for the main diet, genotype, and time yielded a beta coefficient of 2. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes.

Meal replacement One of methods that have been used a lot for preventing weight gain is meal replacement. Different macronutrient compositions in the diet Some researchers have tried changing macronutrient percents to find the most effective dietary mixture for weight maintenance. Randomized trial of lifestyle modification and pharmacotherapy for obesity. Improvements in some cardiovascular disease-risk factors were also observed. Liraglutide, an analog of the incretin hormone glucagon-like peptide-1, is currently approved for the treatment of type 2 diabetes T2D at 1. Respiratory quotient and resting energy expenditure was higher in the capsaicin group, but it had no relationship with weight regain and after treatment it returned to the normal level. For example, weight regain did not occur in individuals who had consumed green tea and caffeine mixture with an adequate or high-protein diet.

From randomization to week 56, weight decreased an additional mean 6. Dietary protein, metabolism, and body-weight regulation: Dose-response effects. There were no attempted or completed suicides. Advanced search.

Participants: adults aged years with a body mass index of 25 or more. Feasibility and validation of a manitenance Columbia-Suicide severity rating scale using interactive voice response technology. Gov't Research Support, U. There were no cases of acute pancreatitis. Conflict of Interest: None declared. Randomization was performed centrally using a telephone- or web-based system.

Comparison of 3 ad libitum diets for weight-loss maintenance, risk of cardiovascular disease, and diabetes: A 6-mo randomized, controlled trial. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. Green tea for weight loss and weight maintenance in overweight or obese adults.

For example, Qi et al 8 reported that individuals with the IRS1 rs CC genotype were more successful with weight loss than those without this genotype when assigned to a low-fat and high-carbohydrate diet vs a low-carbohydrate and dirt diet. Individual variability following 12 weeks of supervised exercise: identification and characterization of compensation for exercise-induced weight loss. Despite the well-known benefits of exercise, the increase in energy expenditure and the potential to decrease hunger and energy intake exercise alone does not seem to be effective at modifying weight status [ 161718 ]. Skip to main content. Contacts and Locations. The date of final follow-up was May 16, Gardner, PhD 1 ; John F.

Human biology of weight maintenance after weight loss. Wirth A, Krause J. Revised : 15 April Participants not pre-selected in this manner may have achieved smaller long-term weight losses.

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