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Hypothyroidism ppt 20111 – Iodine Deficiency Goiter

Drugs Potentially Altering Thyroid Hormone Replacement Requirements Increase replacement requirements Drugs that reduce thyroid hormone production Lithium Iodine-containing medications Amiodarone Cordarone Drugs that reduce thyroid hormone absorption Sucralfate Carafate Ferrous sulfate Slow Fe Cholestyramine Questran Colestipol Colestid Aluminum-containing antacids Calcium products Drugs that increase metabolism of thyroxine Rifampin Rifadin Phenobarbital Carbamazepine Tegretol Warfarin Coumadin Oral hypoglycemic agents Increase thyroxine availability and may decrease replacement requirements Drugs that displace thyroid hormone from protein binding Furosemide Lasix Mefenamic acid Ponstel Salicylates.

David Stewart
Friday, September 29, 2017
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  • This has the potential to be associated with increased fracture risk in later life.

  • Drugs Potentially Altering Thyroid Hormone Replacement Requirements Increase replacement requirements Drugs that reduce thyroid hormone production Lithium Iodine-containing medications 21011 Cordarone Drugs that reduce thyroid hormone absorption Sucralfate Carafate Ferrous sulfate Slow Fe Cholestyramine Questran Colestipol Colestid Aluminum-containing antacids Calcium products Drugs that increase metabolism of thyroxine Rifampin Rifadin Phenobarbital Carbamazepine Tegretol Warfarin Coumadin Oral hypoglycemic agents Increase thyroxine availability and may decrease replacement requirements Drugs that displace thyroid hormone from protein binding Furosemide Lasix Mefenamic acid Ponstel Salicylates. Carousel Previous.

  • Follow up MR analysis on selected instruments The following analyses were conducted on the selected instruments hgpothyroidism in the main MR analysis i. For example, a SNP within the KCNH7 gene was demonstrated to be involved in modulating the treatment response of schizophrenics to the antipsychotic drug risperidone, therefore the gene was recommended as a novel drug target by this study [ 39 ].

  • The following analyses were conducted on the selected instruments identified in the main MR analysis i. Nat Genet —

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In contrast, two studies did not show any difference in BMD following pelvic radiotherapy Bone mineral density deficits and fractures in survivors of childhood cancer. Interestingly, irradiated and nonirradiated patients carry a comparably high risk clearly exceeding the incidence of hypothyroidism in the age-matched general population

Marusyk A, DeGregori J Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. We prioritized these co-localizing eQTLs as pointing to the most likely causal genes and substrate for further hypothyroidism ppt 20111 Tables 1 and 2. It is currently unclear whether this association is a result of cancer treatment or a common etiological pathway Insulin resistance and risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia. Premenopausal females and younger men should be assessed using z scores. A pinhole collimator is used because it magnifies and improves resolution. MR was used to mitigate the confounding that may arise when assessing associations between gene expression and disease, and colocalization was used to verify that the eQTL instrument used in the MR was not coincidentally associated with both traits i.

ASLAM 2. Carousel Previous. Nat Genet. No notes for slide. Thyroxine Achiever. See our Privacy Policy and User Agreement for details. Jul ;92 7

Introduction

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Data from the St. Most people have hypothyroidis, but a small percentage of people may have more or less. Given the following data obtained 6 hours after the capsule was swallowed, what is uptake? A decade in psychiatric GWAS research. Whether chemotherapy is a major cause of pituitary dysfunction is unclear. When there is uncertainty regarding the correct tissue, then it is important to examine instrument effects across a range of applicable tissues rather than relying on a single tissue.

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Structure of the Underlying Research

The extent of impairment of uterine function critically depends on the age of the patient at the time of radiation exposureas the prepubertal uterus is characterized by a significantly higher sensitivity toward radiation-induced damage hypotgyroidism the higher volume pubertal or mature uterus. Additionally, irradiation involving the head and neck may include the thyroid within the radiation field as a risk factor for the development of primary hypothyroidism PH 5475— ThinPrep versus conventional smears cytological preparations in the analysis of thyroid fine-needle aspiration 5-year specimens. In prepubertal children poor growth rate represents the most prominent feature. Studies which seek to enhance statistical power through combining eQTL effects across tissues, such as the MeCs meta-analysis method across brain tissues [ 10 ], will require the assumption of homogeneity of effect across tissues for all loci to be checked beforehand.

Raloxifene improves BMD and reduces the risk hyplthyroidism vertebral, although not nonvertebral, fractures Cell Death Differ — In the well-described ALL cohort, volumetric trabecular BMD rapidly declines within 30 days following induction of therapy but once treatment has completed there is an improvement, but not complete resolution, in trabecular and cortical tibial volumetric BMD defectsand a number of studies show persistently low BMD 20 years or more after treatment 57,although some do not demonstrate any persistent BMD deficit Serum thyroid-stimulating hormone TSH was suppressed. Harpaz N Neoplastic precursor lesions related to the development of cancer in inflammatory bowel disease. The longer-term overall fracture risk in other survivors of childhood and adolescent cancers has not been found to be increased compared with a matched sibling population AI is a rare, yet life-threatening endocrine complication of cancer and its treatment.

  • Serial ultrasound allows for earlier detection but is associated with increased morbidity due to an increased likelihood of detection of benign nodules.

  • Often precipitated by infection or other forms of stress. PhD of Nutrition.

  • In rare cases fertility in cancer survivors may recover. Wicha MS Cancer stem cells and metastasis: Lethal seeds.

  • BMC Med. The problem may be due to the discrepancies between the cytologic and the corresponding histologic pictures because this category embraces BL showing scattered nuclear pleomorphism e.

Clipping is a handy way to collect important slides you want to go back to later. Diana Pavel. Start on. Why not share! Dec ;4 12 Excess iodine can transiently inhibit iodide organification and thyroid hormone synthesis the Wolff-Chiakoff effect. Hypo vs.

In the high-risk survivors and in the non—high-risk survivors, as well hypothyroidism ppt 20111 in sibling controls, prevalence of obesity increased with age and follow-up interval. However, low BMD has also been described in adult patients following treatment of gynecological malignanciesin metastatic testicular cancer patients treated with chemotherapytesticular germ cell tumorhematological malignancies particularly when receiving HSCTchrondrosarcomaEwing sarcomalymphomaand in long-term gastric cancer survivors following gastrectomy The St. In adults, specific guidance exists for patients with breast cancer and nonmetastatic prostate cancersuggesting an assessment of fracture risk and BMD prior to or within 3 months of initiation of aromatase inhibitor or ADT therapy.

Figures and Tables

Table 3 represents an overview of the gonadotoxic potential in female patients in relationship to the main classes and chemotherapeutic agents currently used. Now customize the name of a clipboard to store your clips. A systematic review of patients receiving mainly a combination of radiotherapy and chemotherapy confirmed the impaired sperm count but importantly revealed no DNA damage in the functioning, remaining sperms, which potentially improves fertility management This damage may also result in death or damage to healthy endocrine tissue, leading to glandular dysfunction 36 Anthracyclines, for example, have been demonstrated to reduce blood flow, impair blood vessel wall function, and cause endothelial injury in pediatric patients and patients with breast cancer 39 ,

  • Get Permissions. Higher radiation doses result in an increased probability of developing PHPT

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  • DAB is employed on a grant funded by Biogen. A diagnostic stimulation test to exclude AI should be performed in patients with otherwise unexplained symptoms or signs.

  • Upcoming SlideShare. Thyroid system diagram3 4.

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  • This will lower serum total but not free sex hormone concentrations. Classification of Hypothyroidism A.

Furthermore, patients treated with TBI and HSCT for hematologic malignancies are at high risk for developing treatment-associated infertility and hypogonadism and should therefore be monitored closely Loeb LA Human cancers express a mutator phenotype: Hypothesis, hypothyroidism ppt, and 21011. Additionally, survivors of other solid tumors [CNS tumors e. The appropriate diagnostic stimulation test for CAI remains controversial, as the existing tests to assess HPA function have several limitations. Therefore, in order to more extensively evaluate pleiotropy within the cis-region, the 47 instruments used for the genes identified in our main MR were looked up across the gene transcripts available in AMP-CMC without employing a p-value threshold. Diagnostic efficacy of immunocytochemistry on fine needle aspiration biopsies processed by thin-layer cytology. This can be partially overcome using a calculation based on the vertebral height to adjust the z scores and T-scores—the bone mineral apparent density

The excellent results in this field prompted a wider 20111 to virtually all cytological branches, including thyroid FNAB hypothyroldism212223242526 Diagnostic Cytopathology 36 — doi It improves the accuracy of the morphologic evaluation of these indeterminate lesions enabling a better selection of patients as candidates for surgery from those who should be treated pharmacologically. Multiple predisposing factors for endocrine late effects have been identified, including radiation, sex, and age at the time of diagnosis.

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Iodine Deficiency Goiter

Additionally, I-MIBG therapy has been demonstrated to increase the risk for benign as well as malignant thyroid nodules As hypothyeoidism latency for the development of PHPT is long and younger age at irradiation may be a predisposing factor, young adults receiving head or neck irradiation are considered to be particularly at risk GH replacement therapy in GH-deficient adult cancer survivors remains controversial.

Drew Chambers. Post Ablative - Permanent - Transient - Sub-clinical 4. Carousel Previous Carousel Next. Classification of Hypothyroidism A.

Following irradiation, endocrine organs such as the thyroid are also at risk for subsequent malignancies. The distribution of brain tumors in the adult population differs from that observed in childhood patients with cancer. Descriptive statistics for the morphologic and immunocytochemical yieldings in all cytologic categories and only in follicular neoplasm lesions. A potential issue with the MR analysis could be that the gene expression changes are a consequence of genetic predisposition to disease rather than a cause of the disease. It is not taken up by the salivary glands, the long half life allows imaging after the target to background ratio has become higher and there has been urinary exretion of much of the dose. We prioritized these co-localizing eQTLs as pointing to the most likely causal genes and substrate for further analyses Tables 1 and 2. The p steiger statistic indicates the strength of evidence that the relationship is in the correct direction from exposure to outcome.

Export Citation. The relative hypotyhroidism for thyroid cancer after treatment with chemotherapy in childhood were 3. It is also possible that regions may fail to colocalize due to lack of statistical power and multiple causal variants in the region, which may obscure association peaks that would colocalize after conditional analysis is conducted across the region. As a rule in our institution, lesions classified as FN Thy 3 undergo immunocytochemical analysis for HBME-1 and Galectin-3 expression: those showing a simultaneous positivity for both antibodies are referred to surgery whereas those exhibiting a simultaneous negativity should be carefully followed-up, with the surgical option being held for potential future use. Nat Genet.

However, this possibility is still speculative and the majority of authors feel that the diagnosis of indeterminate cytology is still unavoidable. Low BMD is being described in an increasing number of adult cancer survivors. Histopathology 41 — doi The many faces of pleiotropy.

S12 Table. Farber E, Cameron R The sequential analysis of cancer development. Cancel Save. These findings should therefore be considered as having more borderline evidence of colocalization. However, fine-needle biopsy should be performed by experienced physicians to improve its validity Whereas medulloblastoma Generally, diagnosis of secondary thyroid cancer in long-term cancer survivors should be performed equivalent to the approach to patients from the general population.

Specific hypothyroidism ppt 20111 of chemotherapy damage to individual endocrine glands are discussed hyptohyroidism the respective chapters, where data are available. Following irradiation, endocrine organs such as the thyroid are also at risk for subsequent malignancies. In rare cases fertility in cancer survivors may recover. Am J Pathol — It improves adult height, although the adult height potential might not be fully achieved due to additional factors such as other endocrine dysfunction chronic illness and spinal or direct bone-related effects due to irradiation 95 Cytometry 9: — Therefore, the cases diagnosed as such are often addressed to surgery that results in a large amount of inappropriate thyroidectomies.

Show More. Hypothyroidism by Vitrag Shah views Hypothyroidism --a clinical perspec Myxedema 43 Causes of Hypothyroidism 9.

Importantly, note that owing to the potentially impaired bioactivity of TSH, central hypothyroidism cannot be diagnosed using TSH as a screening marker of thyroid function, and all patients at risk need fT4 measurements. It is hypothyroidism ppt 20111 possible that regions may fail to colocalize due to lack of statistical power and multiple causal variants in the region, which may obscure association peaks that would colocalize after conditional analysis is conducted across the region. In a large European study of almost 40, patients only 0. In this perspective, LBC is an improvement of conventional cytology as it represents an invaluable storage for the cellular material that can be successfully used for additional investigations. The German guideline for endocrine long-term follow-up of childhood cancer survivors, however, proposes a regular assessment of serum calcium for patients at risk 4. J Clin Oncol. Possible effects of hyperprolactinemia as a consequence of impaired gonadotropin secretion are reduced libido, ED in menand galactorrhea and amenorrhea in women.

Cancel Save. Actions Shares. Genetics of congenital hypothyroidism. Now customize the name of a clipboard to store your clips. It releases hormones that control metabolism—the way your body uses energy. Drew Chambers.

Table 3. PLoS Comput Biol 3: Diagn Mol Pathol 5: 3—9. Loss-of RERE function results in an early-onset neurodevelopmental disorder with anomalies in the brain, eye and heart OMIM [ 1920 ], and haploinsufficiency for RERE variants with assumed milder impact are believed to contribute to neurological abnormalities in adults [ 21 ].

  • Like this presentation? Gene identified in the main MR analysis is highlighted in bold.

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  • As a consequence, pubertal development in children may be delayed or arrested, or in some patients with central late effects precocious puberty is observed. The majority of hot nodules seen on thyroid scans are benign.

  • Newborn screening results in children with central hypothyroidism. Upcoming SlideShare.

No Downloads. Ankit G Singh. See our Privacy Policy and User Agreement for details. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Galactorrhea 5.

ALSO READ: Carpal Tunnel Syndrome Caused By Hypothyroidism Diet

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As these complications occur during or shortly after cancer treatment, they are in a strict sense not considered treatment-related late effects. The SNM recommends that patients wait 2—4 weeks after examinations using iodinated contrast agents before having a thyroid uptake measurement, but many departments recommend up to 6 weeks. Curr Med Res Opin. However, during the advancement of puberty, sensitivity to irradiation changes.

We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. WordPress Shortcode. Forskolin support thyroid hormone secretion. Like this presentation? Praja Pratama. Like this presentation? This will lower serum total but not free sex hormone concentrations.

TSH c. Primary hypogonadism has also been described in survivors of unilateral malignant ovarian tumors In fact, out of 22 cases of HBME-1 positivity and Galectin-3 negativity 13 resulted in malignancy Discovering drugs that efficiently treat brain diseases has been challenging. This is important, because such genes may encode effective drug targets for these diseases. Multiple hot and relatively cold regions throughout both lobes with apparent suppression of non-nodular gland. WordPress Shortcode.

Some studies found no difference between pediatric cancer survivors and either control subjects or general population incidence figureswith others demonstrating higher incidence in adult cancer survivors of pediatric tumors hyopthyroidism A delayed TSH response to TRH and a diminished nocturnal TSH surge may be helpful indicators, as these qualitative changes are suggestive of dysfunction of the hypothalamic control of the thyroid axis. Original z score— and T-score—based algorithms have been more recently replaced by fracture risk assessment in combination with BMD measurements. Abstract Design Fine-needle aspiration biopsy FNAB is the most reliable diagnostic tool in the diagnosis of thyroid nodules. Parathyroid carcinomas are generally rare but have also been reported to occur secondary to irradiation— MR and colocalization analyses identified 23 potentially causal genes with evidence of a shared genetic effect between gene expression eQTL and schizophrenia risk Table 1.

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Mdms Payoe. Clipping is hypothyroidism ppt 20111 handy way to collect important slides you want to go back to later. Free T3 4. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads.

Genes Chromosomes Cancer — Additionally, hyperprolactinemia and precocious puberty in children can occur as a result of pituitary hyperactivity following cancer treatment. Major osteoporotic fractures are generally diagnosed with plain radiographs following presentation with pain. Hypoparathyroidism may occur after thyroid or neck surgery, after I therapy, or in patients with autoimmune disease Why not share!

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All MN and BL were histologically confirmed. Figure 3 illustrates disorders of pubertal development, hypogonadism and infertility in male patients following hypothyroidism ppt 20111 therapy. Symptoms such as loss of libido may thus be difficult to judge on clinical grounds. In clinical practice it is difficult to isolate the direct effect of chemotherapy from other contributory factors such as GCs, radiotherapy, and chemotherapy-induced hypogonadism. Free access.

  • Exopthalmus, or protrusion of the eyeballs, may be seen in hyperthyroid patients. Trends Genet 30—

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  • Design Fine-needle aspiration biopsy FNAB is the most reliable diagnostic tool in the diagnosis of thyroid nodules. Descriptive statistics of the studies which were selected as the primary outcomes for our MR analysis.

  • TSH 2. Consider glucocorticoids for AI, which can coexist with thyroid disease.

Those obtained at 24 hours will have a lower count rate, but images may be superior due to the decreased body background. Steiger filtering analysis results conducted on our prioritised gene instruments. Stainier D No stem cell is an islet yet. The rate of nonsurgically induced POF at age 40 was 9. The cytologic criteria for diagnosing FN are not universally accepted and the category itself is debated.

Forty-three out of 59 hypothyroidism ppt of SM We conducted a MR phenome-wide association analysis MR-PheWAS on disease outcomes and risk factors, previously collated by Zheng et al [ 62 ] S15 Table to assess the potential for pleiotropic relationships across traits. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. Low BMD is well described as a consequence of treatment of childhood, adolescent, and adult cancers. Whiteside TL The tumor microenvironment and its role in promoting tumor growth. J Pathol —

Liu D, Hornsby PJ Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. In case of scant cellularity, which is defined as not 6 groups of follicular cells, the immunocytochemical diagnosis should not be made. Interestingly, a substantial proportion of eQTLs 1, or Clipping is a handy way to collect important slides you want to go back to later. Fertility should be discussed and assessed by semen analysis according to patient choice after sufficient counseling.

  • We then conducted colocalization analysis between the gene expression and the outcome detected in our primary MR. Psychological treatment should be offered to all men with concerns about sexual function.

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  • The published literature regarding late effects after cancer treatment is dominated by observations derived from cancer survivors of childhood and adolescent cancer.

  • These subgroups are characterized by a significant difference in the risk that a MN is being detected at histology Longitudinal assessment of BMD should be assessed using the same modality if any meaningful change is to be detected

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Like Liked. Full Name Comment goes here. They are rich in iodine and essential nutrients that maintain thyroid function balance. Successfully reported this slideshow.

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The simultaneous analysis of multiple targets and next-generation sequencing offer the best practical approach for the evaluation of tumor progression, understanding their heterogeneity and cell segregation. Assessment of tissue-specific effects. TRH b. The rate of POF observed following chemotherapy underestimates these risks, which are higher in patients with posttreatment amenorrhea because they may resume normal menstrual cycles following initial cancer treatment even following initial temporary amenorrhea. Beyond radiotherapy, however, more evidence is accumulating to suggest that rib fractures are highly predictive of future fracture and may be associated with low BMD ,

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Low-dose cranial irradiation in patients with acute lymphoblastic leukemia ALL or total body irradiation TBI in patients undergoing stem cell transplantation has been demonstrated as a major risk factor for HP dysfunction, especially GHD 61hypothyroiism Hypothyroidism or in rare cases even hyperthyroidism can develop during or shortly after therapy but may also emerge decades after the end of treatment. These subgroups are characterized by a significant difference in the risk that a MN is being detected at histology Although diagnosis and management of functional and neoplastic long-term consequences of cancer therapy are comparable to other causes of endocrine disorders, cancer survivors need individually structured follow-up care in specialized surveillance centers to improve care for this rapidly growing group of patients.

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Use of GH therapy in cancer survivors varies between different countries and depends on several endpoints Given the following data obtained 6 hours after the capsule was swallowed, what is uptake? Fractionation of the doses may be more detrimental as the better studied single radiation dose

Show related SlideShares at end. It releases hormones that control metabolism—the way your body uses energy. You can change your ad preferences anytime. If you continue browsing the site, you agree to the use of cookies on this website. Ketan Bhandari. Like this presentation?

Opera WinfreyOpera is a new guest to Hypothyroid community!!! Stop and compare these symptoms with those of Bill Loney. Hypothyroidism 1. Cancel Save.

These patients are therefore at greater risk for treatment-related late effects Diagnostic Cytopathology 23 6 — 13 doi Harpaz N Neoplastic precursor lesions related to the development of cancer in inflammatory guided and unguided media examples of obsessive compulsive personality disease. When sex hormones are low, deprivation symptoms such as hot flashes and sexual dysfunction may occur. Risk is further determined by patient-related factors such as age and genetic predisposition as well as additional chemotherapy that may alter the dose-response relationship for the development of SMN after radiotherapy In adults diagnosis is not specific for cancer survivors but follows general guidelines as exemplified by the Endocrine Society guideline on hypogonadism CAI, however, evolves slowly over time and affects a high proportion of brain tumor survivors.

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Radiotherapy constitutes the main risk factor for the development of hypothyroidism ppt 20111 dysfunction and neoplasms in the irradiated gland. The relative risks for thyroid cancer after treatment with chemotherapy in childhood were 3. Table 1 Cytohistological comparison cases. TRH b.

Now customize the name of a clipboard to store your clips. Open navigation menu. Clipping is a handy way to collect important slides you want to go back to later. Jun ;7 3 The following potential causes should be considered : Pituitary adenoma-exerting pressure on normal pituitary cells Tumors impinging on hypothalamus Lymphocytic hypophysitis- cause death of cells.

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