Advertisement

Sign up for our daily newsletter

Advertisement

Subclinical hypothyroidism and depression: Subclinical Hypothyroidism and Depression: A Systematic Review and Meta-Analysis

Hypothyroid patients frequently experience problems such as apathy, depression, psychomotor slowing, and cognitive dysfunction. A reappraisal using objective psychological measurement.

David Stewart
Tuesday, October 31, 2017
Advertisement
  • Contact us Submission enquiries: bmcpsychiatry biomedcentral.

  • A flow chart of the meta-analysis is shown in Figure 1. Some studies reported that the prevalence of depression is higher in persons with SCH than in euthyroid people, 47 while others found the risk for depression is comparable between the two population 68.

  • Am J Med. The primary endpoint was the development of incident depressive symptoms in this study population.

  • We also evaluated the mean depression scores among individuals with SCH, compared with their euthyroid counterparts based on the depression scales used.

Site branding

Background: Although depression is associated with changes in the hypothalamic-pituitary-thyroid axis, its relationship with subclinical hypothyroidism SCH is controversial. However, a recent randomized, blinded, crossover study failed to find differences in symptoms, quality of life, or depression when DTE was substituted for L-T4 The answer is because hypothyroidism is also more prevalent among women than in men.

Xia Chen moc. Age Ageing. Am J Psychiatry ; 3 — Open Next post in Depression Advisor Close. Article Google Scholar 9. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.

Google Scholar. A flow chart of the meta-analysis is shown in Figure 1. A reappraisal using objective psychological measurement. Structural clinical interview for diagnostic and statistical manual of mental disorders fourth edition. Prog Neuropsychopharmacol Biol Psychiatry. Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism. To avoid missing any relevant papers, we also reviewed the reference lists of key reports for related articles.

SCH may impact up to A 6-month randomized trial of thyroxine treatment in women with mild subclinical subclinucal. We performed a meta-analysis of the available evidence from cross-sectional reports and both prospective and retrospective studies investigating the relationship between SCH and depressive scale. If published papers only provided the percentage of depressive symptoms, the evaluator calculated the numbers of participants by the calculator in Revman version 5. Thyroid status, disability and cognitive function, and survival in old age. Among these studies, Park et al. Support Center Support Center.

Publication types

Larisch et al. Funding Not applicable. The estimated SMD was 0. All duplicates were removed.

  • We performed a meta-analysis of the available evidence from cross-sectional reports and both prospective and retrospective studies investigating the relationship between SCH and depressive scale.

  • Studies show that subjects on thyroxine have poorer psychological wellbeing than their healthy counterparts with no thyroid diseases and it only confirms the relationship between hypothyroidism and depression.

  • No significant difference was observed in the composite end point between the L-T4 therapy group and placebo group in SCH patients Fig.

  • Scientists concluded that administration of SSRIs in hypothyroid patients was safe [xiv].

Volume Arch Med Subclinial. Falling threshold for treatment of borderline subclinical hypothyroidism and depression thyrotropin levels-balancing benefits and risks: evidence from a large community-based study. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Subclinical thyroid dysfunction and depressive symptoms among the elderly: A prospective cohort study. Scientists concluded that administration of SSRIs in hypothyroid patients was safe [xiv].

Subclinical hypothyroidism and depression could also indicate depresskon stronger relationship between two conditions which will be discussed below. Reuters VS, et al. Figure 2. Two reviewers screened potential articles independently and a third reviewer made the final decision when discrepancies were found with a specific study. This website we is strictly for the purpose of providing opinions of the author s.

  • Occup Med Oxford. Psychopathological and cognitive features in subclinical hypothyroidism.

  • Psychological Medicine Oc A total of 21 studies were included in the qualitative analysis.

  • Parsaik, A.

  • Lifelong estradiol exposure and risk hypothyeoidism depressive symptoms during the transition to menopause and postmenopause. Data, including study name, characteristics of the study population age, race, and sexmain conclusion sdiagnostic criteria, number of SCH participants with depression and the total number of SCH patients, the number of euthyroid participants with depression, the total number of euthyroid participants were extracted.

  • A probable interpretation of this disparity could be the over-diagnosis of SCH among the elderly due to the lack of age-associated serum TSH reference ranges in the original studies included in the meta-analysis

Kim J-M. J Affect Disord. Subclinical hypothyroidism increases the risk for depression in the subclinical hypothyroidism and depression. The connection among overt thyroid dysfunction, abnormal mood, and cognitive disorder has been well documented 12. At present, it may be reasonable to initiate treatment of mild hypothyroidism in patients with affective complaints, but realistic expectations should be set regarding the likelihood of symptom resolution. The hospital anxiety and depression scale.

Try out PMC Labs and tell us what you think. Any discrepancies were resolved by a third reviewer LHS. Depression, being one of the common chronically disabling disorders, can lead to poor quality of life [ 12 ]. In recent years, many publications have paid increasing attention to the relationship between SCH and depression; however, these studies revealed tremendous heterogeneity in the recruited population, particularly in terms of age, gender, and depressive domains. This article has been cited by other articles in PMC. Background: Thyroid function is closely associated with neuropsychological functions, including mental state and cognitive functions. Hong et al.

Associated Data

The subclinical hypothyroidism and depression is scored from zero to nine stars, and the highest score indicates the best methodological quality. Both SSRIs and tricyclic antidepressants appear to amplify the activity of deiodinase enzyme type 2 D2 thereby leading to the enhanced conversion of T4 in active T3 in the brain. Two reviewers conducted this step independently and disagreements were resolved by consensus.

  • Endocrine 45— Brennan, M.

  • The authors appropriately accounted for a number of relevant covariates, including age, sex, body mass index, smoking status, alcohol use, exercise, and medical comorbidities.

  • Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. This result indicates that only older participants are more susceptible to SCH.

  • Meta-analyses are known to be confounded by the comprehensiveness of search strategy, reporting quality of included studies, publication bias and exclusion of non-English articles.

  • However, in animal studies, thyroid hormones affect the neurotransmission of serotonin and noradrenaline, which play critical roles in the pathogenesis of depression and are the targets of current antidepressant therapy 38 — Try out PMC Labs and tell us what you think.

  • Transl Psychiatry.

Mol Psychiatry. In fact, the largest studies found no differences in depression between euthyroid and subclinical hypothyroid patients, either at baseline or when patients were followed over time depression4. For instance, a study about gender differences in depression and anxiety, based on the Netherlands population, found that women reported a younger age of onset of single and recurrent major depressive disorder MDD than men. Psychiatry Investig. First, some data were obtained from observational studies, many of which are cross-sectional studies. Protein levels of beta-catenin and activation state of glycogen synthase kinase-3beta in major depression.

Of note, it has become increasingly common in the elderly as normal aging itself is associated with biochemical changes in the HPT axis. Psychiatric symptoms and diagnoses in thyroid disorders: a cross-sectional study. Am J Geriatr Psychiatry. Ellos escuchan. Stott, D.

Full Image

Moreover, the relationship between depressive symptoms and SCH is controversial, particularly in older patients, as the prevalence of SCH increases with age. Kim et al. Depressive symptoms in patients with subclinical hypothyroidism—the effect of treatment with levothyroxine: a double-blind randomized clinical trial.

SCH, subclinical hypothyroidism; CI, confidence interval. Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults. Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U. Reversible morbidity markers in subclinical hypothyroidism.

We found an insignificant difference for the subclinical hypothyroidism and depression endpoint: standard mean difference SMD of 0. Notably, articles involving participants varying in age may affect mutual comparability. Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction? We performed a sub-group analysis because of the clinical heterogeneity. High-affinity ZnT8 autoantibodies by electrochemiluminescence assay improve risk prediction for type 1 diabetes. They found that estrogen levels could affect thyroid function and contribute to thyroid disorders [xvi].

SYSTEMATIC REVIEW article

Second, our findings strongly support the routine examination of thyroid function in participants with depression in the clinic. Learn More. When we pooled the data from these four studies, elderly individuals with SCH had a 1.

  • Among these studies, Park et al.

  • Checklists of methodological issues for review authors to consider when including non-randomized studies in systematic reviews. Expert Opin Drug Saf.

  • Deiodinases: implications of the local control of thyroid hormone action. Moreover, the relationship between depressive symptoms and SCH is controversial, particularly in older patients, as the prevalence of SCH increases with age.

  • Subclinical hypothyroidism: psychiatric disorders and symptoms. Taken together, SCH and depression may share common biological mechanisms, which is in support of our findings.

New issue alert. Email alerts Article activity alert. The PubMed, Embase, and Web of Science literature databases were searched, without restriction of language, for publications up to August XD and YZ: data extraction.

ALSO READ: Acquired Von Willebrand Disease Hypothyroidism In Dogs

Overall, this meta-analysis indicates that SCH is not linked to depression, which was defined by a diagnosis of depression or an hypoothyroidism on the depressive scale. Endocrinol Metab Clin North Am. General Psychiatry 2048—63 Anxiety, depression, and quality of life in primary care patients. CSF triiodothyronine rT3 levels in patients with affective disorders. Study characteristics were summarized. Thyroid function and the natural history of depression: findings from the Caerphilly Prospective Study CaPS and a meta-analysis.

Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction? Brennan, M. A flow chart of the meta-analysis is shown in Figure 1. Hypothalamic-pituitary-thyroid-axis function in treatment resistant depression. J Clin Invest.

Moreover, the relationship between depressive symptoms and SCH is controversial, particularly in older patients, as the prevalence depression SCH increases with subclinjcal. Subclinical hypothyroidism and cognitive impairment: systematic review and meta-analysis. Despite these limitations, the current meta-analysis has enhanced the statistical power by pooling the results of the studies. Funding Not applicable. Depression, anxiety, health-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction.

References

J Nerv Mental Dis. Rev Bras Psiquiatr. Another reasonable interpretation is that many older patients with biochemical outcomes consistent with SCH would have reverted to a normal thyroid function state without L-T4 replacement.

Park YJ, et al. Home » Thyroid » Hypothyroidism and Depression Connection. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. Front Endocrinol. Despite these limitations, the current meta-analysis has enhanced the statistical power by pooling the results of the studies.

For example:. Google Scholar. Endocr Res. SCH may impact up subclinical hypothyroidism and depression The table above shows that not only hypothyroidism and depression have hypothyrojdism symptoms in common, but depression is also a symptom of an underactive thyroid gland. Thus, it is possible that certain subsets of L-T4 patients may in fact have depressive symptoms due to decreased intracellular thyroid hormone levels, although the data are quite preliminary. Supplemental legends 13K, docx.

Background

Eur J Endocrinol. Roberts LM, et al. This is also the time when women are either approaching or they have gone through a menopause transition.

  • Meta-analyses are known to be confounded by the comprehensiveness of search strategy, reporting quality of included studies, publication bias and exclusion of non-English articles. Contact USA.

  • Many studies have been conducted on this subject, but they yielded different results.

  • Depression, anxiety, health-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction. Two studies found a higher prevalence of depression between elderly with SCH compared to controls [ 1430 ].

  • This finding is similar to our results. Reviews, case reports, letters, nonhuman studies, and conference abstracts were eliminated.

J Affect Disord. Hypothyroid patients frequently experience problems such as apathy, depression, psychomotor slowing, and cognitive dysfunction. Second, symptoms are more apparent when patients are aware of their thyroid status, suggesting that they may be related to the self-knowledge of thyroid disease. Sign In. Pooled analysis for subclinical hypothyroidism and depression.

A paradoxical difference in subclinical hypothyroidism and depression between anxiety, depression and thyroid function in subjects on and not on T4: findings from the HUNT study. Garmendia Madariaga. A total of 21 studies were included in the qualitative analysis. Some past observational studies reported an increased prevalence of depression in subclinical hypothyroid patients compared with the general population 1.

Want to read more?

Endocrine 45— Second, the included reports were designed as observational studies case control, cross-sectional, and cohort studies with different qnd collection methods retrospective and prospective. A reappraisal using objective psychological measurement. Low mood and response to Levothyroxine treatment in Indian patients with subclinical hypothyroidism. Recently, many publications have investigated whether SCH is connected to a higher risk of cognitive damage and depression in older populations 262728 ,

The connection among depeession thyroid dysfunction, abnormal mood, and cognitive disorder has been well documented 12. Karege, F. J Nerv Mental Dis. There was no difference in mean TSH between individuals with depression and healthy controls 2. Subclinical hypothyroidism, mood, and cognition in older adults: a review. Psychiatry Res. Metrics details.

Among these 21 studies, 8 showed significant associations between SCH and depression, while the other 13 did not show this relationship. We performed a sub-group analysis because of the clinical heterogeneity. We assessed the pooled effect size using a random effects model when considerable statistical heterogeneity was assumed; for contradistinction, we also chose a fixed effects model. Thyroid function and the natural history of depression: findings from the Caerphilly Prospective Study CaPS and a meta-analysis. The aging thyroid. Studies from Korea, the Netherlands, and Norway showed null associations between SCH and depression, while all the studies from Brazil showed significant associations. The hospital anxiety and depression scale.

Account Options

View Metrics. The cohort was drawn largely from employees of local companies and government agencies and their spouses and so subclinical hypothyroidism and depression younger and likely healthier than the overall population. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. Thyroid Jul;19 7 Therefore, the use of various scales for the detection and quantification of depression may be limited by methodological heterogeneity, disturbing the horizontal comparisons among different studies.

Nord J Psychiatry. A total of 21 studies were included in the qualitative analysis. Thyroid hormone therapy for older adults with subclinical hypothyroidism. Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment. We here recommend the CES-D scale for future studies involved in this area 35which is generally recommended for the primary screening of depression in community care or primary care, as it has shown great sensitivity and specificity in both young and elderly populations Reasons, why hypothyroid patients may have a poor wellbeing due to thyroxine, are numerous and a possible explanation is the misattribution of symptoms.

Almeida et al. Many of the included articles did not re-examine the thyroid hormone levels over time. Treatment for primary hypothyroidism: current approaches and future possibilities. Advises kids to take care of themselves by communicating about the problem and joining support groups such as Alateen.

Introduction

The PubMed, Embase, and Web of Science literature databases were searched, without restriction of language, for publications up to August Am J Geriatr Psychiatry. Another possible explanation for persistent symptoms in some L-T4—treated patients regards polymorphisms in the deiodinase 2 or thyroid hormone transporter genes 3. E-mail: samuelsm ohsu.

  • A forest plot was used to present the pooled OR value, and heterogeneity was evaluated using the I 2 statistic.

  • Overt hypothyroidism is a cause of major mood disorder, including melancholia, and may result in deteriorating dementia 1. The funnel plot is a straightforward approach of investigating whether publication bias is present.

  • Front Cell Neurosci.

  • In a seminal series of nine individuals with refractory depression, on top of antidepressant and levothyroxine depression, additional administration of liothyronine was associated with marked improvement in the symptoms of depression in seven of them [ 57 ]. Conclusions: This meta-analysis demonstrated that SCH was positively associated with the risk of depression, especially in persons above 50 years of age, suggesting it is necessary to pay close attention to depressive symptoms in persons with SCH.

  • Depressive symptoms and major depressive disorder in patients affected by subclinical hypothyroidism a cross-sectional study. View Metrics.

Recently, a paper from New England found no significant differences in the mean alteration in the Tiredness score or Hypothyroid Symptoms score over a 1-year period between a placebo group and an Hypothyroidlsm treatment group among older people with SCH. Serotonin exerts a repressive effect on thyrotropin-releasing hormone TRH excretion, suggesting the presence of a feedback loop that permits the activation of the hypothalamus-pituitary-thyroid axis if serotonin values in the brain are relatively low. This meta-analysis demonstrates that there is a higher prevalence of depression in persons with SCH, raising some suggestions for clinical practice. Among these 21 studies, 8 showed significant associations between SCH and depression, while the other 13 did not show this relationship. Many of the included articles did not re-examine the thyroid hormone levels over time. We also observed no relationship between SCH and depression in older patients.

ALSO READ: Goiter Iodine Excess And Hypothyroidism

Journal of Clinical Endocrinology and Metabolism Subclinical hypothyroidism and depression. Subsequently, we collected the full versions of the qualified reports. Hypothyroiidsm presence of publication bias was assessed by the combination of Egger's test, Begg's test, and visual inspection of the funnel plot. Effects of selective serotonin reuptake inhibitors on thyroid function in depressed patients with primary hypothyroidism or normal thyroid function. These could theoretically lead to lower intracellular levels of active thyroid hormones, even with normal circulating TSH and T3 levels. The quality of the literature for the analyzed studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale.

Suicide attempts were assessed using a screening hylothyroidism instead of subclinical hypothyroidism and depression validated questionnaire, and the study did not use a healthy control group. In addition, using the SMD as the endpoints, no significant effect was observed Supplementary Figure 4. Published online Jun 4. Download references. Thyroid stimulating hormone, cognitive impairment and depression in an older Korean population.

Acknowledgments

Studies Sections and Data Extraction Selected studies were eligible if they met the following criteria: 1 SCH was confirmed by elevated TSH levels and circulating thyroid hormones within the normal range; and 2 the study was a cross-sectional, case-control, or cohort study. SCH participants were diagnosed according to the specific diagnostic criteria in each included study Table 1 and the controls for these studies included participants with euthyroid function. These inconsistent results could be attributed to the heterogeneous study populations, small sample size, lack of control arm for comparison and differences in study design.

The NOS includes eight items regarding selection, comparability, and depression and consequence. Arq Bras Endocrinol Metabol. This finding is similar to our results. The main drawback of these studies was that participants in some cohorts were not representative and outcome assessment was self-reported questionnaires ; however, this is typically inevitable for these types of studies.

A 30 year old male was diagnosed with hypothyroidism Depreseion 19, 12 Front Endocrinol Lausanne. In euthyroid participants, the dose-response relationship between thyroid hormone levels and depressive symptoms was determined. If published papers only provided the percentage of depressive symptoms, the evaluator calculated the numbers of participants by the calculator in Revman version 5. Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction? Two reviewers Zhao and Chen separately evaluated all potential titles and abstracts. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam study.

Both SSRIs and tricyclic antidepressants appear to amplify the activity of deiodinase enzyme type 2 D2 thereby leading to the enhanced conversion of T4 in active T3 in the brain. Depression-like behavior in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. Surks MI, et al.

Suhclinical for publication Not applicable. Its relevance to subclinical hypothyroidism and depression illness. Five other studies showed no difference in the number of individuals with depression between SCH and control group [ 815202130 ], whereas three found no difference in the depression scores [ 131517 ]. Memory improvement with treatment of hypothyroidism.

Recently, several reports have focused on subclinical hypothyroidism SCH and its latent neuropsychiatric and neurocognitive outcomes; however, these studies have failed to determine the precise nature and strength of this relationship. This method can lead to the potential misclassification of normal thyroid hormone participants who only have a transient elevation in the serum TSH level. A Booklet for Families Created for family members of people with alcohol abuse or drug abuse problems. Figure 3. Study characteristics Table 1 illustrates the characteristics of the five cross-sectional and nine prospective studies included in the meta-analysis. Depressive symptoms and major depressive disorder in patients affected by subclinical hypothyroidism: a cross-sectional study.

Describes the emergency department treatment process, lists and depression to ask about follow-up treatment, and describes how to reduce risk and ensure safety at home. Skip to main content. If you wish to read unlimited content, please log in or register below. The role of thyroid hormones in depression. Elevated thyroid peroxidase antibody increases risk of post-partum depression by decreasing prefrontal cortex BDNF and 5-HT levels in mice.

Ge, J. If published papers only provided the percentage of depressive symptoms, the evaluator calculated the numbers of participants by the calculator in Revman version 5. Arch Gerontol Geriatr. Front Endocrinol Lausanne. The link between thyroid function and depression. Article Google Scholar.

Pasqualetti, G. Expert Opin Drug Saf. Thyroid and adrenal axis in major depression: a controlled study in outpatients. Data analysis was performed by AY. It affects 3 to 8. Blum et al.

Age Ageing. Depression is not just a persistent feeling of sadness; it is a serious health condition indicated by symptoms affecting both mental and physical annd depression wellbeing. Home » Thyroid » Hypothyroidism and Depression Connection. Are autoimmune thyroid dysfunction and depression related? SE, standard error; OR, odds ratio. Overt hypothyroidism is a cause of major mood disorder, including melancholia, and may result in deteriorating dementia 1. Previous studies investigating possible links between depression and reference-range thyroid hormone levels have been variable, although the largest and best conducted reported no correlations 1.

The relationship between thyroid function and depressive symptoms-the FIN-D2D population-based study. Subclinical hypothyroidism SCH is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life QoL in elderly subjects. Background: Thyroid function is closely associated with neuropsychological functions, including mental state and cognitive functions.

Consistent with the distinct original data, we chose different effect models. A study with postmortem prefrontal cortex. Subclinical hypothyroidism and depression aspects of hypothyroidism and treatment reversibility. Given the findings summarized above and the valuable contribution by Kim et al. Despite these limitations, the current meta-analysis has enhanced the statistical power by pooling the results of the studies. Therefore, it is likely that a significant number of patients in this study who had subclinical hypothyroidism at baseline had normal TSH levels on repeat measurement. Additional Information: We only recommend products that we believe in.

Subclinical hypothyroidism SCH is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life QoL in elderly subjects. Dissent was resolved by consensus and the recommendation of a third observer Zhao as required. Some studies reported that the prevalence of depression is higher in persons with SCH than in euthyroid people, 47 while others found the risk for depression is comparable between the two population 68. This article has been cited by other articles in PMC. In addition, all participants were not limited by age group, geographical region, or race. Subclinical hypothyroidism and depression: a meta-analysis.

Psychopathological and cognitive features in subclinical hypothyroidism. PubMed Article Google Scholar. Subclinical hypothyroidism SCH is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life QoL in elderly subjects. TSH 3.

  • Mental changes accompanying thyroid gland dysfunction.

  • This could also indicate a stronger relationship between two conditions which will be discussed below.

  • Nevertheless, further studies which examine the variations between intracerebral and peripheral thyroid hormones and TSH levels in different populations are required to allow a better understanding of this complex relationship.

Therefore, it is likely that a significant and depression of patients in this anf who had subclinical hypothyroidism at baseline had normal TSH levels on repeat measurement. Hypothyroidism and Depression. Horm Metab Res. However, several limitations should be taken into consideration. The cohort was drawn largely from employees of local companies and government agencies and their spouses and so was younger and likely healthier than the overall population. In addition, SCH may result from antithyroid treatment in patients with Graves' disease. Journal List Transl Psychiatry v.

Given the evidence summarized above, it is not surprising that patients with mild hypothyroidism do not reliably experience relief of affective symptoms with L-T4 therapy. Santin A. SCH may impact up to The presence of publication bias was assessed by the combination of Egger's test, Begg's test, and visual inspection of the funnel plot. An association between depression, anxiety and thyroid function—a clinical fact or an artefact? In total, articles were identified by the preliminary search of articles published by June 10, ; of these articles, were more comprehensively evaluated and 17 papers were finally selected for the meta-analysis Supplementary Figures 1. Subclinical hypothyroidism SCH is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life QoL in elderly subjects.

Thyroid Jul;19 7 In addition, SCH may result from antithyroid treatment in patients with Graves' disease. Hypothyroidism requires adequate management and to make it happen, your doctor will probably prescribe thyroid hormone replacement therapy i. Please review our privacy policy.

  • Pasqualetti, G. Nevertheless, further studies which examine the variations between intracerebral and peripheral thyroid hormones and TSH levels in different populations are required to allow a better understanding of this complex relationship.

  • They found that estrogen levels could affect thyroid function and contribute to thyroid disorders [xvi].

  • Reversible morbidity markers in subclinical hypothyroidism.

  • Increased atherogenic low-density lipoprotein cholesterol in untreated subclinical hypothyroidism. Ann Thorac Surg.

Thyroid function hgpothyroidism the natural history of depression findings from the Caerphilly Prospective Study CaPS and a meta-analysis. Cognitive and affective status in mild hypothyroidism and interactions with L-thyroxine treatment. In total, 4. Stott et al. A flow chart of the meta-analysis is shown in Figure 1. Characteristics of included studies.

Villar H. Helfand, M. A total of 21 studies were included in the qualitative analysis. We will not ask you for any personal information. TSH 4. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Third, there may be possible bias due to the heterogeneity of the analyzed studies in terms of the definition of SCH and the evaluation of depression.

A randomized controlled trial of the effect of thyroxine replacement on cognitive function a 30 year old male was diagnosed with hypothyroidism community-living elderly subjects with subclinical hypothyroidism: the Birmingham Elderly Thyroid study. Subclinical hypothyroidism SCH is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life QoL in elderly subjects. Both hypothyroidism and depression are common conditions and they have numerous things in common.

A randomized controlled trial of the effect of thyroxine replacement on cognitive function in community-living elderly subjects an subclinical hypothyroidism: the Birmingham Elderly Thyroid study. In one large cross-sectional subclinical hypothyroidism and depression, there was no association between the Thr92Ala polymorphism in deiodinase 2 and quality of life in euthyroid patients 18but in another study, L-T4—treated patients with the same polymorphism had decrements in psychological well-being and mood compared with patients without this polymorphism Depression is more prevalent than we think. Further studies using multiple age-associated TSH reference ranges can provide a better evaluation of the risk of depression in SCH patients.

Tags: depression link research study. TSH, free T4, and free triiodothyronine T3 were measured and depression each visit. Falling depreswion for treatment of borderline elevated thyrotropin levels-balancing benefits and risks: evidence from a large community-based study. Med Care. Results Study selection In total, articles were identified by the preliminary search of articles published by June 10, ; of these articles, were more comprehensively evaluated and 17 papers were finally selected for the meta-analysis Supplementary Figures 1.

  • Prog Neuropsychopharmacol Biol Psychiatry.

  • This is supported by the literature: in a population-based study of over 25, patients, there was no correlation between thyroid function and self-reported depression overall, but the subgroup with known thyroid disease had an increased risk of depression, despite normal TSH levels

  • Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals. Thyroid hormone replacement for subclinical hypothyroidism.

Hypothyroidusm information specialists answer calls, transfer callers to state services or other appropriate intake centers in their states, and connect them with local assistance and support. Metrics details. Abstract Background Although depression is associated with changes in the hypothalamic-pituitary-thyroid axis, its relationship with subclinical hypothyroidism SCH is controversial. Health status, psychological symptoms, mood, and cognition in L-thyroxine-treated hypothyroid subjects. The PubMed, Embase, and Web of Science literature databases were searched, without restriction of language, for publications up to August Sawin, C.

Abstract Background: Although depression is associated with changes in the hypothalamic-pituitary-thyroid axis, its subclinical hypothyroidism and depression with subclinical hypothyroidism SCH is controversial. Subclinical hypothyroidism depresion incident depression in young and middle age adults. Subclinical thyroid dysfunction and depressive symptoms among the elderly: A prospective cohort study. For cross-sectional studies, the common deficiency was the lack of a direct description of response rates and the completeness of data collection that could be determined. Sometimes, the lack of understanding the causes of certain symptoms can impair the treatment and weaken psychological wellbeing of a patient.

Sidebar1?
Sidebar2?