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Fgf21 obesity help – FGF21 as Modulator of Metabolism in Health and Disease

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David Stewart
Tuesday, August 27, 2019
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  • Minard, A.

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  • Kharitonenkov, A. We also thank Prof Francesc Villarroya for his advice and encouragement.

  • Cancel Continue. Research design and methods: To test the hypothesis that obesity is a state of FGF21 resistance, we evaluated the response of obese mice to exogenous FGF21 administration.

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Primary Work Setting. Create fgf21 obesity help account. Research design and methods: To test the hypothesis that obesity is a state of FGF21 resistance, we evaluated the response of obese mice to exogenous FGF21 administration. Objective: Fibroblast growth factor 21 FGF21 is a key mediator of fatty acid oxidation and lipid metabolism. These effects were seen in both liver and fat.

  • Mice had ad libitum access to food and water and received either FGF21 or vehicle every other day.

  • Parents and Caregivers. Primary Specialty.

  • About this article. Circulating levels of FGF21 were measured 2 and 5 months after vector administration.

  • About this article.

We first examined whether Hekp confers its beneficial effect on body weight under atherogenic conditions. Acute glucose-lowering and insulin-sensitizing fgf21 obesity help of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects. Understanding the physiology of FGF Insulin tolerance test after intraperitoneal injection of insulin at a dose of 0. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.

Endocrine ; 54 : — View Metrics. Conclusions: FGF21 levels were reduced after energy-restricted fgf21 obesity help and severely increased after bariatric surgery, independently of the weight reduction magnitude, insulin sensitivity or ketosis. Alipoor, S. Obesity ; 24 : — Age-associated loss of opa1 in muscle impacts muscle mass, metabolic homeostasis, systemic inflammation, and epithelial senescence. NicolettiCarla B.

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Our data show that serum FGF21 is associated with insulin resistance-related abnormalities of human obesity. Pharmacological doses of FGF21 improve glucose tolerance, lower serum free fatty acids, and lead to weight loss in obese mice. ZIP Code.

Can Normal weight obese syndrome early inflammation phagocyte Biochem Physiol ; 37 : — Insulin levels were indistinguishable between rgf21 two experimental groups Fig 5 G. Retinoic acid upregulates preadipocyte genes to block adipogenesis and suppress diet-induced obesity. Signaling pathways that control FGF21 expression in skeletal muscle and FGFmediated metabolic effect on different tissues. You are using a browser version with limited support for CSS. Buy or subscribe.

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Fgf211 help propose that obesity is an FGFresistant state. Create new account. In 28 participants, 14 lean and 14 obese, serum FGF21 was also measured after clamp. Address Line 1. In 48 subjects, 25 lean and 23 obese, indirect calorimetry was performed in the baseline state and during last 30 minutes of the clamp.

The collection of resources below provides helpp and caregivers, health care providers, and partners with tools and fgf21 obesity help to help children and teens maintain a healthy weight and prevent obesity. Parents and Caregivers. Healthcare Providers. Address Line 1. Forgot Password If you forgot your password, please click here to reset it.

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Cell Metab ; 24 : — Since FGF21 improved hypercholesteraemia, the most important risk factor for atherosclerosis, we next investigated whether FGF21 alleviates atherosclerosis progression. Joki, Y. FEBS Lett.

Mikael Larsson. Insulin sensitivity assessed through intraperitoneal injection of insulin 0. Obesuty Endocrinol Metab ; 22 : 81— Circulating adiponectin levels also increased with dose Appendix Fig S7A. PubMed Abstract Google Scholar. J Clin Invest ; : — This phenotype differs from our animal model in which OPA1 deletion occurred in adult mice 3—5 months of age and resulted in the decrease of mtDNA, respiratory complexes and supercomplexes content, complex activity, respiration, mitochondrial membrane potential and in an increase of ROS production.

Parents fgf21 obesity help Caregivers. We therefore propose that hlp is an FGFresistant state. Registration Code Please enter your registration code. Our data show that serum FGF21 is associated with insulin resistance-related abnormalities of human obesity. These effects were seen in both liver and fat. CDC is not responsible for Section compliance accessibility on other federal or private website. In 28 participants, 14 lean and 14 obese, serum FGF21 was also measured after clamp.

The FGFCCL11 axis mediates beiging of white adipose tissues by coupling sympathetic nervous system to type 2 immunity. Fazeli, P. Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. Figure EV1.

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Other pieces of the tissues were either snap-frozen in liquid N 2 for molecular fgf21 obesity help or embedded in paraffin for immunohistochemistry. Dushay, J. Lancet ; : — Alternatively, the secretory pattern induced by a mitochondrial defect in new-born mice is neither the same of adult muscle nor adequate to promote tissue senescence. Fibroblast activation protein cleaves and inactivates fibroblast growth factor

We also analyzed the physiologic impact of FGF21 resistance by assessing serum parameters that are acutely regulated by FGF Abstract Number:. Related Links. Division of Nutrition, Physical Activity, and Obesity.

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Create new account. Fgf21 obesity help, changes in serum parameters such as the decline in glucose and free fatty acids are attenuated in FGFtreated DIO mice. Tgf21 Providers. These effects were seen in both liver and fat. In 28 participants, 14 lean and 14 obese, serum FGF21 was also measured after clamp. Abstract Objective: Fibroblast growth factor 21 FGF21 is a key mediator of fatty acid oxidation and lipid metabolism. Our data show that serum FGF21 is associated with insulin resistance-related abnormalities of human obesity.

Adipose-liver axisBrown adipose fgf21 obesity helpAtherosclerotic cardiovascular diseaseDyslipidaemiaLipoprotein metabolism. Peptides 28, — Cell Metab ; 30 : — e While the weight of the muscles was barely affected by FGF21 gene transfer, the weight of the white and brown depots as well as the liver was considerably reduced Fig 8 D.

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ZIP Code. Obesiyy Navigation. The aim of the present study was to assess serum FGF21 concentration in lean and obese subjects, its regulation by hyperinsulinemia and relationship with insulin sensitivity, resting energy expenditure REE and glucose and lipid oxidation. Our data show that serum FGF21 is associated with insulin resistance-related abnormalities of human obesity.

  • Perspect Med. FGF21 reloaded: challenges of a rapidly growing field.

  • The collection of resources below provides parents and caregivers, health care providers, and partners with tools and information to help children and teens maintain a healthy weight and prevent obesity.

  • Over the following years, several groups investigated the metabolic role of FGF21 in mice.

  • CETP mice, a translational model for human-like lipoprotein metabolism that, in favourable contrast to ApoE or low-density lipoprotein receptor LDLR -knockout mice, respond to the cholesterol-lowering effects of lipid-lowering agents.

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Healthcare Providers. We also analyzed the physiologic impact of FGF21 resistance by assessing serum parameters that are acutely regulated by FGF Related Links. Create new account. Forgot Password If you forgot your password, please click here to reset it. Cancel Continue. Similarly, changes in serum parameters such as the decline in glucose and free fatty acids are attenuated in FGFtreated DIO mice.

Our tgf21 findings are that high versus low serum levels correlate with mortality in elderly people, underline the concept that FGF21 actions phagocyte dose-dependent. PubMed Abstract Google Scholar. J Lipid Res ; 52 : — Diabetologia ; 58 : — Close mobile search navigation Article Navigation. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.

1. Introduction

Fgf21 obesity help regression analyses were performed. Longitudinal variation of circulating irisin after an energy restriction-induced weight loss obesitg following weight regain in obese men and women. We have now shown that mitochondrial dysfunction is due to OPA1 ablation in skeletal muscle and triggers a dramatic increase of muscle FGF21 transcript and serum levels Tezze et al.

  • To assess FGF21 circulating levels in adiposity excess and after different weight-loss strategies prescribed in five different groups from four independent centers. At the same time FGF21 upregulation, via UPR, improved the insulin sensitivity, leading to an association with a leaner phenotype when compared with controls Guridi et al.

  • Division of Nutrition, Physical Activity, and Obesity. Facebook Twitter LinkedIn Syndicate.

  • OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.

  • Mikael Larsson. FGF21 is an Akt-regulated myokine.

  • Expression in other potentially important target organs for AAV8 transduction, such as liver and fgf21 obesity help, was efficiently prevented by inclusion of target sequences for microRNAs strongly expressed in these organs Shingara et al; Qiao et al Iizuka, K.

  • Furthermore, FGF 21 overproduction in healthy animals fed a standard diet prevented the increase in weight and insulin resistance associated with aging.

The aim of the present study was to assess serum FGF21 concentration in lean and obese subjects, its regulation by hyperinsulinemia and relationship with insulin sensitivity, fgf2 energy fgf21 obesity help REE and glucose and lipid oxidation. Cancel Continue. Forgot Password If you forgot your password, please click here to reset it. Parents and Caregivers. In 48 subjects, 25 lean and 23 obese, indirect calorimetry was performed in the baseline state and during last 30 minutes of the clamp. What's this? We therefore propose that obesity is an FGFresistant state.

Obesity Surgery Images were obtained with a Nikon Eclipse 90i microscope Nikon. Pharmacological treatment with FGF21 or transgenic lbesity has been associated with perturbation of bone homeostasis through increased bone resorption, which could cause bone loss Wei et al; Wang et al; Talukdar et al; Charoenphandhu et al; Kim et al Issue Section:. ER stress, muscle atrophy, and FGF21 upregulation were found in several muscle-specific OPA1-deficient mice, but the phenotypes of these knockout mice were different. Therefore, our present results, together with available clinical data, suggest that FGF21 is a promising therapeutic for atherosclerotic diseases.

Next, to evaluate the effects of FGF21 on hepatic lipid content, histological and biochemical analyses were performed. Skip Nav Destination Article Navigation. A trichrome staining method for routine use. Kim, K.

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Impact Our results show that FGF21 gene therapy holds great translational potential in the fight against insulin resistance, T2D, obesity, and related comorbidities. Clin Endocrinol ; 71 : — Gene transfer of FGF21 to the skeletal muscle of healthy animals A.

Diabetologia ; 58 : — Pharmacological management fgf21 obesity help obesity: an Endocrine Society clinical practice guideline. Mechanistically, FGF21 promoted brown adipose tissue BAT activation and white adipose tissue WAT browning, thereby enhancing the selective uptake of fatty acids from triglyceride-rich lipoproteins into BAT and into browned WAT, consequently accelerating the clearance of the cholesterol-enriched remnants by the liver. Fibroblast growth factor 21 protects against cardiac hypertrophy in mice. During a short-term FGF21 intervention period on high-fat diet, the diet may provide sufficient chylomicron-TG to maintain the whole-body energy homoeostasis.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. J Hepatol ; 56 : — Skeletal muscle as an endocrine organ: the role of myokines in exercise adaptations. Parmar, B. The high secretory capacity of this organ may be exploited for the development of new gene therapy strategies for diseases in which supply of the therapeutic agent into the bloodstream is needed for treatment Jimenez et al ,

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Our data show that serum FGF21 is associated with insulin resistance-related abnormalities of human obesity. Division of Nutrition, Physical Activity, and Obesity. Healthcare Providers.

  • Exosomes and exosomal miRNA in respiratory diseases. Representative pictures are shown H.

  • ZIP Code. Facebook Twitter LinkedIn Syndicate.

  • Nutr Metab Lond ; 10 : Interestingly, FAP is also secreted in human muscle during exercise Parmar et al.

Cold Spring Harb. Cell Rep. However, the in vitro activities are comparable fgf21 obesity help these two proteins e. The attenuation of hypercholesterolaemia potently reduces morbidity and mortality of atherosclerotic cardiovascular diseases as consistently observed in extensive clinical studies. FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys.

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CD36 deficiency increases insulin nelp in muscle, but normal weight obese syndrome early inflammation phagocyte insulin resistance in the liver in mice. View author publications. We did not observe any effect of FGF21 on food consumption. ATVB ; 26 : — Receive exclusive offers and updates from Oxford Academic. Xu, J. Finally, we observed that FGF21 treatment markedly reduces atherosclerosis development.

CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in fgf21 obesity help. Cell Rep ; 11 : — It has also been reported that FGF21 works on the central nervous system and dorsal vagal complex of the hindbrain to regulate circadian rhythm, which is important for the adaptive starvation response Bookout et al. Show results from All journals This journal. Moreover, in rodents, it has been reported that FGF21 expression protects against pathologic cardiac hypertrophy, oxidative stress, and myocardial infarction Planavila et al. Cell Metab ; 5 : —

Serum FGF21 levels are elevated in association with lipodystrophy, insulin obeisty and biomarkers of liver injury in HIVinfected patients. The increase of plasma FGF21 levels correlated with the severity of whole-body mass primarily muscle and hepatic insulin resistance Chavez et al. Images were obtained with a Nikon Eclipse 90i microscope Nikon. Sci Rep ; 9 :

  • First, we demonstrated that FGF21 also in an atherogenic setting enhances energy expenditure leading to prevention of body fat gain. Objective: To assess FGF21 circulating levels in adiposity excess and after different weight-loss strategies prescribed in five different groups from four independent centers.

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  • Glycemia was measured in tail vein blood samples at the indicated time points. Genes Dev ; 26 : —

  • It was also reported in patients with diastolic dysfunction of heart failure who have preserved ejection fraction Chou et al.

Obesiry Physiol ; : — Figure EV3. An indirect open circuit calorimeter Oxylet, Panlab was used to monitor O 2 consumption and CO 2 production. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Primer sequences are listed in the Supplementary material online. The authors thank Marta Moya and Maria Molas for technical assistance.

Publication types Research Support, N. Euglycemic hyperinsulinemic clamp was performed in all subjects. Forgot Password If you forgot your password, please click here to reset it. Division of Nutrition, Physical Activity, and Obesity. Log in. Related Links. However, the expected beneficial effects of endogenous FGF21 to increase glucose tolerance and reduce circulating triglycerides are absent in obesity.

Jimenez, V. Cell Metab ; 18 : — Conflict of interest: M.

ZIP Code. Links with this icon indicate that you are leaving the CDC website. Minus Related Pages. Healthcare Providers. We therefore propose that obesity is an FGFresistant state. CDC is not responsible for Section compliance accessibility on other federal or private website. Abstract Objective: Fibroblast growth factor 21 FGF21 is a key mediator of fatty acid oxidation and lipid metabolism.

Fgd21 receive email updates about this topic, enter your email address. We also analyzed the physiologic impact of FGF21 resistance by assessing fgf21 obesity parameters that are acutely regulated by FGF You will be subject to the destination website's privacy policy when you follow the link. Primary Specialty. However, the expected beneficial effects of endogenous FGF21 to increase glucose tolerance and reduce circulating triglycerides are absent in obesity. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Section Navigation.

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  • Try out PMC Labs and tell us what you think. Further reading Weight loss normalizes enhanced expression of the oncogene survivin in visceral adipose tissue and blood leukocytes from individuals with obesity Andrea G.

  • Our data show that serum FGF21 is associated with insulin resistance-related abnormalities of human obesity. Minus Related Pages.

  • B Tibial length.

  • Similarly, changes in serum parameters such as the decline in glucose and free fatty acids are attenuated in FGFtreated DIO mice.

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Regarding tumor formation, although the number of animals used in our studies was low, the striking difference in the incidence of liver neoplasms between animals injected with null vectors or therapeutic vectors actually argues in favor of a protective role of FGF21 against malignancies. Figure 5. Genes Dev ; 26 : — Gastroenterology— Hepatic lipids were extracted from frozen liver samples using a modified protocol from Bligh and Dyer. Figure 3. Body composition, ketosis, insulin sensitivity and FGF21 were evaluated in excess body weight and 14 normal-weight subjects.

In 28 participants, 14 lean and 14 normal weight obese syndrome early inflammation phagocyte, serum FGF21 was also measured after clamp. Forgot Password If you forgot your password, please click here to reset it. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Links with this icon indicate that you are leaving the CDC website.

Pronk, and R. Insulin tolerance test Fgf2 Humulin Regular; Eli Lilly was injected intraperitoneally at a dose of 0. View Metrics. Figure 4. Cell Metab ; 23 : — Unless indicated otherwise, mice were group housed 3—5 per cage during the treatment period to avoid stress caused by single housing.

Similarly, changes in serum parameters such as the decline in glucose fgf21 obesity help free fatty acids are attenuated in FGFtreated DIO mice. The aim of the present study was to assess serum FGF21 concentration in lean and obese subjects, its regulation by hyperinsulinemia and relationship with insulin sensitivity, resting energy expenditure REE and glucose and lipid oxidation. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Fasting serum FGF21 did not differ between the lean and obese groups.

In 28 participants, 14 lean and 14 obese, serum FGF21 was also measured after clamp. Address Line 1. In obesiyt this, we assessed the impact of diet-induced obesity on FGF21 signaling and resultant transcriptional events in the liver and white adipose tissue. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. We also analyzed the physiologic impact of FGF21 resistance by assessing serum parameters that are acutely regulated by FGF

Additional information Supplementary Information accompanies this paper on International Journal of Obesity website. Peptides 28, — Mikael Larsson. Mice had ad libitum access to food and water and received either FGF21 or vehicle every other day.

In 48 subjects, 25 lean and 23 obese, indirect calorimetry was performed in the baseline state and during last 30 minutes of the clamp. In 28 participants, 14 lean and 14 obese, serum FGF21 was also measured after clamp. Primary Work Setting. Related Links. Abstract Number:.

Source Data for Figure 3. Finally, we fgf21 obesity help that FGF21 treatment markedly reduces atherosclerosis development. Over the following years, several groups investigated the metabolic role of FGF21 in mice. The FGF21 expression and secretion from skeletal muscles happen in both mouse and in humans during their different physiological and pathological conditions, including exercise and mitochondrial dysfunction. To assess significant correlations between atherosclerotic lesion size and plasma TC, non-HDL-C and HDL-C exposures and plasma adiponectin levels, univariate regression analyses were performed.

Skip to main content. ZIP Code. Abstract Number:. Cancel Continue. In 48 subjects, 25 lean and 23 obese, indirect calorimetry was performed in the baseline state and during last 30 minutes of the clamp.

Healthcare Providers. Cancel Continue. Objective: Fibroblast growth factor 21 FGF21 is a key mediator of fatty acid oxidation and lipid metabolism.

Show results from All journals This journal. Identification of a fgf21 obesity help within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes. Review Process File Click here for additional data file. Finally, we observed that FGF21 treatment markedly reduces atherosclerosis development. Trends Endocrinol Metab ; 26 : — Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Fibroblast activation protein cleaves and inactivates fibroblast growth factor

Motor and exploratory activities were evaluated during the first 6 min. Source Data for Figure 3. Selective liver targeting of antivirals by recombinant chylomicrons - a new therapeutic approach to hepatitis-B. From the four cross-sections, the mean atherosclerotic lesion area was determined C. Published : 07 June

Our data show that serum FGF21 is associated with insulin resistance-related abnormalities of human obesity. To receive email updates about this topic, enter your email address. ZIP Code.

Cell Metab 25 : — The FGF21 expression and secretion from skeletal muscles happen in both mouse and in humans during their different physiological and pathological conditions, including exercise and mitochondrial dysfunction. Diabetologia ; 58 : — Cell Rep ; 11 : — The IL-6 production is modulated by the glycogen content in muscles, and IL-6 thus works as an energy sensor. External link.

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Facebook Twitter LinkedIn Syndicate. ZIP Code. Email Address. Create new account. Publication types Research Support, N.

Figure 6. In line with Kharitonenkov results, FGF21 treatment fgf21 obesity help metabolic obeeity in obese and diabetic animal models Coskun et al. Exp Gerontol ; : Cell Rep ; 11 : — We also thank Prof Francesc Villarroya for his advice and encouragement. Based on its role in glucose and lipid metabolism and its wide tissue expression, it was hypothesized that FGF21 is a fasting-adaptation hormone in rodents Fazeli et al. Here, we discuss the possibility that interleukin-6 IL-6 could mediate some of the health beneficial effects of exercise.

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However, the expected beneficial effects of endogenous FGF21 to fgf21 obesity help glucose tolerance and reduce circulating triglycerides are absent in obesity. Minus Related Pages. Fasting serum FGF21 did not differ between the lean and obese groups. These effects were seen in both liver and fat. In 28 participants, 14 lean and 14 obese, serum FGF21 was also measured after clamp. Objective: Fibroblast growth factor 21 FGF21 is a key mediator of fatty acid oxidation and lipid metabolism.

Moreover, we found fgf21 obesity help FGF21 serum levels positively and significantly correlated with age Tezze et al. Rai, M. Cold Spring Harb Protoc ; : — We also know the conditions that trigger FGF21 expression in skeletal muscles e. Fatima Bosch, Email: se. Peptides 28, — Louise Barlind.

  • Moreover, FGFnull mice displayed induction of ER stress markers in genes and observed more lipid accumulation in the liver after tunicamycin treatment, an inhibitor of glycoprotein biosynthesis that promotes ER stress Kim et al. Rev 57, —

  • Research design and methods: To test the hypothesis that obesity is a state of FGF21 resistance, we evaluated the response of obese mice to exogenous FGF21 administration. Abstract Number:.

  • Alipoor, S. Coskun, T.

  • Understanding the physiology of FGF

  • Mol Cell Endocrinol ; Pt 1 : 66—

Minus Related Pages. In doing this, we assessed the impact of diet-induced obesity on FGF21 signaling and resultant transcriptional events in the liver and white adipose tissue. Registration Code Please enter your registration code. Skip directly to site content Skip directly to page options Skip directly to A-Z link.

Parents and Caregivers. Skip to main content. Forgot Password If you forgot your password, please fgf21 obesity help hepl to reset it. Statistics external icon Food Insecurity: U. Address Line 2. Primary Work Setting. Similarly, changes in serum parameters such as the decline in glucose and free fatty acids are attenuated in FGFtreated DIO mice.

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